Glycogen synthase kinase 3 controls endochondral bone development: Contribution of fibroblast growth factor 18
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چکیده
منابع مشابه
Glycogen synthase kinase 3 controls endochondral bone development: contribution of fibroblast growth factor 18.
Glycogen synthase kinase 3 (GSK3) inhibits signaling pathways that are essential for bone development. To study the requirement for GSK activity during endochondral bone development, we inhibited GSK3 in cultured metatarsal bones with pharmacological antagonists. Interestingly, we find that inhibition of GSK3 strongly repressed chondrocyte and perichondrial osteoblast differentiation. Moreover,...
متن کاملGlycogen Synthase Kinase-3
1Department of Pathology and Centre for Neuroscience, The University of Melbourne and Mental Health Research Institute, Parkville, VIC 3010, Australia 2Neurosignalling Group, Garvan Institute for Medical Research, 384 Victoria St. Darlinghurst, Sydney, NSW 2010, Australia 3Membrane Biology Group, Centre for Integrative Physiology, University of Edinburgh, George Square, Edinburgh EH8 9XD, UK 4 ...
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ژورنال
عنوان ژورنال: Developmental Biology
سال: 2005
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2005.07.029